Our mission is to develop a quantitative understanding of somatic evolution in tissues to detect cancer at its earliest stages
We are a new research group, part of the CRUK Cambridge Center Early Detection Program. Our work aims to understand how mutant clones arise, expand and compete in our tissues as we age. Focusing predominantly on blood, we use novel genetic lineage tracking tools and deep sequencing of longitudinal samples to identify mutant clones which are under strong positive selection. Such clones are implicated in early cancer and thus are candidates for improved cancer detection.