No evidence of immunosurveillance in mutation-hotspot driven clonal haematopoiesis

B. Walkowiak, H.A.J. MacGregor, J.R. Blundell

bioRxiv (2024)

Evolutionary dynamics in the decades preceding Acute myelooid leukaemia

C.J. Watson, Y.P.G. Poon, H.A.J. MacGregor, A.V.A. Fonseca, S. Apostolidou, A. Gentry-Maharaj, U. Menon, J.R. Blundell

bioRxiv (2024), in revision, Nature

Modelling the age-related deceleration of clonal haematopoiesis in UK Biobank

H. A. J. MacGregor, D. F. Easton and J. R. Blundell

bioRxiv (2023)

Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution

Y. P. G. Poon, A. Vedi, M. Sanders, E. Laurenti, P. Valk and J. R. Blundell

Cell Genomics (2024, accepted)

The Mutation rates and fitness consequences of mosaic chromosomal alterations in blood

C.J. Watson and J. R. Blundell

Nature Genetics, 55, 1677-1685 (2023)

Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues

Y. P. G. Poon, C. J. Watson, D. S. Fisher, J. R. Blundell

Nature Genetics, 53, 1597–1605 (2021)

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The Evolutionary Dynamics and Fitness Landscape of Clonal Haematopoiesis

C. J Watson, A. Papula, Y. P. G. Poon, W. H. Wong, A. L. Young, T. E. Druley, D. S. Fisher, J. R. Blundell

Science, 367, 1149-1154 (2020)

See video abstract here

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the dynamics of genetic diversity during the early stages of clonal evolution

J. R. Blundell, K. Schwartz, D. Francois, D. S. Fisher, G. Sherlock and S. F. Levy 

Nature Ecology & Evolution, 3, p293–301 (2019)

A scalable double-barcode sequencing platform for characterization of dynamic protein-protein interactions

U. Schlecht*, Z. Liu*, J. R. Blundell, R. P. St. Onge, S. F. Levy. *Equal contribution

Nature Communications 8, 15586 (2017)

Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast

S. Venkataram*, B. Dunn*, Y. Li, A. Argawala, J. Chang, E. Ebel, K. Geiler-Samerotte, L. Herrisant, J. R. Blundell, S. F. Levy, D. S. Fisher, G. Sherlock, D.A. Petrov. *Equal contribution

Cell  166, 1585-1596 (2016)

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The obstruction of adaptation in diploids by recessive deleterious alleles

Z.J. Assaf, D.A. Petrov*, J. R. Blundell*. *Equal contribution 

PNAS 112(20), 2658-2666 (2015)

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Quantitative evolutionary dynamics using high-resolution lineage tracking

S. F. Levy*, J. R. Blundell*, S. Venkataram, D. A. Petrov, D. S. Fisher and G. Sherlock. *Equal contribution 

Nature 519 181-186 (2015)

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