Our mission is to develop a quantitative understanding of somatic evolution in tissues to detect cancer at its earliest stages
We are a research group in the CRUK Cambridge Center Early Detection Programme. Our work aims to understand how mutant clones arise, expand and compete in our tissues as we age. Focusing predominantly on blood, we use novel genetic lineage tracking tools and deep sequencing of longitudinal human blood samples to study the earliest stages of evolution of cancer from healthy tissue. We aim to use this understanding for improved cancer detection and risk stratification.