Our mission is to develop a quantitative understanding of somatic evolution in tissues to detect cancer at its earliest stages 

 

We are a research group in the CRUK Cambridge Center Early Detection Programme. Our work aims to understand how mutant clones arise, expand and compete in our tissues as we age. Focusing predominantly on blood, we use novel genetic lineage tracking tools and deep sequencing of longitudinal human blood samples to study the earliest stages of evolution of cancer from healthy tissue. We aim to use this understanding for improved cancer detection and risk stratification.

Group photo, December 2018. Jonathon Cordova, Caroline Watson, Adriana Fonseca, Gladys Poon, Jinqi Fu, Jamie Blundell, Oliver, Hulme, Ramana Carthigesan, and, Caroline Worster

Group photo, December 2018. Jonathon Cordova, Caroline Watson, Adriana Fonseca, Gladys Poon, Jinqi Fu, Jamie Blundell, Oliver, Hulme, Ramana Carthigesan, and, Caroline Worster